Bio F1B

Bio 14.6

Bio TO-2

Bio F1D

Bio NT

Bio HT

Bio 87.20

Bio 15.16

Bio 1.5

Bio Golden Syrian

Bio F1B

Description

The Bio F1B Hybrid is genetically-defined hamster, derived from two highly inbred lines, namely by crossbreeding between Bio 87.20 female with a Bio 1.5 male. The Bio F1B hamsters have been used in research since early 1980's. Initially the Bio F1B was used as a genetically defined control for cardiomyopathic and myopathic hamsters. Later, the Bio F1B became an exciting animal model for hyperlipidemic-related applications. 
These hamster have a relatively large body size and  lifespan.  They are also rigid and can withstand surgical procedures well.


Applications:

  • Hyperlipidemia
  • Hypercholesterolemia
  • Atherosclerosis
  • Atherosclerosis regression
  • Diabetics
  • Inhalation Toxicology
  • Gait
  • ECG abnormalities

 
 


Lipid Profile:

  • Presence of plasma CETP vs. absence in rats and mice
  • Has high plasma LDL as compared to other hamsters
  • Has high response in LDL with moderate cholesterol diet
  • Has high response in Atherosclerosis moderate cholesterol diets
  • Has high uniformity among individuals and has a high reproductibility in response to treatment as they are genetic defined
  • These hamsters have a blood lipid profile similar to humans.

F1B Literature
Kowala,M.C.; Nicolosi,R.J. 1989 Effect of doxazosin on plasma lipids and atherogenesis: a preliminary report