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covid 19 Diagnosis test series
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covid 19 Diagnosis test series

CDC has developed two laboratory tests that identify SARS-CoV-2, the virus that causes COVID-19. The first test for COVID-19 diagnosis that CDC distributed, released in February 2020, is the CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel, a test that accurately detects SARS-CoV-2 in respiratory specimens. CDC released a second assay in July 2020, the CDC Influenza SARS-CoV-2 (Flu SC2) Multiplex Assay, which permits public health laboratories to run three tests in a single reaction well. The Flu SC2 Multiplex is more efficient in its use of test reagents, allows higher throughput, and simultaneously gives accurate results about the presence of SARS-CoV-2, influenza A, and influenza B nucleic acid in a patient specimen. Symptoms for COVID-19 and the Flu can be similar, so testing for all three viruses at the same time will provide public health officials with information they need to help reduce the spread of these viruses in the community while conserving resources that are in short supply.

Please note: CDC will discontinue the CDC 2019-nCoV Real-time RT-PCR Diagnostic Panel at the end of 2021. For more details, please see the CDC 2019-nCoV Real-time RT-PCR Diagnostic Panel section below.

Introduction

Compared to 2002/2003 SARS-CoV and 2012–2014 MERS-CoV epidemics, COVID-19 coronavirus rapidly spread to other parts of the world (185 countries and territories, Last updated: March 21, 2020)().

In symptomatic patients, the clinical manifestations of the disease usually start after less than a week, consisting of fever (body temperature 37 to 38°C), cough, nasal congestion, and fatigue (). Pneumonia mostly occurs in the second or third week of a symptomatic infection (). Comparison of hematological parameters between mild and severe cases of COVID-19 showed significant differences in interleukin-6 (IL-6), D-Dimer, glucose (GLU), thrombin time (TT), fibrinogen (FIB) and C-reactive protein (CRP) (). Fan et al. analyzed the hematological indices of COVID‐19 infected patients between the intensive care unit (ICU) and non‐ICU patients. They showed lymphopenia and raised lactate dehydrogenase (LDH) were associated with higher rate of ICU admissions. Patients who were transferred to the ICU had a lower nadir lymphocyte count, nadir monocyte count and nadir hemoglobin, and higher peak Neutrophil (NEU) Count and peak LDH levels compared to patients who did not require ICU stay () . Many patients with MERS-CoV had liver function abnormalities with elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and LDH (). Also laboratory data on SARS have shown that most patients had elevated CRP levels, lymphopenia, leukopenia, and elevated levels of aminotransferase, LDH and creatine kinase (). A series of recently published articles have reported the epidemiological and clinical characteristics of patients with COVID-19 disease, but data regarding the laboratory characteristics of infected individuals are limited (–). This study aimed to evaluate the accuracy of laboratory parameters in predicting cases with positive RT-PCR for COVID-19.

covid 19 Diagnosis test series
    covid 19 Diagnosis test series

Methods

Study design and setting

This diagnostic accuracy study was conducted on suspected COVID-19 patients, who presented to Behpooyan Clinic Medical center in Tehran (Iran) from 22 February to 14 March, 2020. Patients were divided into two groups based on the results of real time reverse transcriptase‐polymerase chain reaction (RT-PCR) for COVID-19 and the accuracy of different laboratory parameters in predicting cases with positive RT-PCR was evaluated using area under the ROC curve (AUC). The study protocol was approved by the Ethics Committee of Shahid Beheshti University of Medical Sciences (ethical code: IR.SBMU.RETECH.REC.1399.010).

Participants

Outpatients with suspected COVID-19 having initial respiratory signs (including sore throat without shortness of breath), fever, cough, muscle ache, and headache were included ().

Data gathering

Pharyngeal swab samples were collected for COVID-19 test on presentation. Blood samples were collected from each participant and routine blood test including White blood cell count (WBC), Lymphocyte count (LYM), and Neutrophil count (NEU) were performed on the blood samples. Furthermore, blood biochemistry parameters such as Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Urea, C-reactive protein (CRP), as well as Albumin and lactate dehydrogenase (LDH) were assessed using HITACHI 7600-020 automated biochemistry analyzer.

Nadal COVID-19 IgG/IgM Test
BSV-243001N-10 10 tests
EUR 316
Description: Nadal COVID-19 IgG/IgM Test

COVID-19 IgG.IgM Rapid Test, Cs
R0180C 30
EUR 0.9

COVID-19 Real-Time PCR Test
P0180 96
EUR 5275

GA COVID-19 Rapid Antigen Test
BSV-3980 20 tests
EUR 500
Description: GA COVID-19 Rapid Antigen Test

COVID-19 IgG/IgM Rapid Test Kit
UNCOV-20 20T/kit
EUR 186
Description: COVID-19 IgG/IgM Rapid Test (Serum/Plasma/Whole Blood) is a qualitative membrane-based immunoassay for the detection of COVID-19 antibodies in serum, plasma, or whole blood. This test consists of two test lines, an IgG line and an IgM line, which is pre-coated with two mouse anti-human monoclonal antibodies separately. During testing, the sample reacts with COVID-19 antigen-coated on conjugated pad. As the complex continues to travel up the strip, the anti-COVID-19 IgM antibodies are bound on the IgM line, and the anti-COVID-19 IgG antibodies are bound on the IgG line. The control(C)line appears when sample has flowed through the strip. The presence of anti-COVID-19 IgM and/or IgG will be indicated by a visible test line in the IgM and IgG region. To serve as a procedural control, the control line should always appear if the test procedure is performed properly and the reagents are working as intended.

Innovita COVID-19 IgG/IgM Rapid Test
BSV-RAPID-02 40 tests
EUR 1011
Description: Innovita COVID-19 IgG/IgM Rapid Test

COVID-19 Antigen Rapid Test Pen (Saliva)
BSV-COV-2PEN20 20 pc
EUR 177
Description: COVID-19 Antigen Rapid Test Pen (Saliva)

COVID- 19 RNA Test, Self-testing CE, 1 test/pack
U20252 test Ask for price

Panbio™ COVID-19 IgG/IgM Rapid Test
ICO-T402 25 Tests/Kit
EUR 264

COVID-19 Ag Rapid Test External Control Kit
C0182 each
EUR 520

COVID-19 IgG/IgM Rapid Test Development Kit
MBS2563888-500Tests 500Tests
EUR 500

COVID-19 IgG/IgM Rapid Test Development Kit
MBS2563888-5x500Tests 5x500Tests
EUR 2225

Flu A & Flu B & Covid-19 Ag Rapid Test
GF101A3 25 Test/kit Ask for price

COVID-19 Antigen Test Kit (colloidal gold method)
TRI-K03M1S 50T
EUR 277.2

COVID-19 Antigen Test Kit (colloidal gold method)
TRI-K03S1S 25T
EUR 141.12

Rapid Response COVID-19 Saliva Rapid Antigen Test
BSV-COV-2C25B 25 tests
EUR 316
Description: Rapid Response COVID-19 Saliva Rapid Antigen Test

COVID-19 + Influenza A. B Ag Rapid Test, Cs
R0188C 1fi Ask for price

Human COVID-19 Spike RBD IgG ELISA Test Kit
MBS1563045-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike RBD IgM ELISA Test Kit
MBS1563046-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike RBD IgA ELISA Test Kit
MBS1563047-96Tests 96Tests
EUR 605

COVID-19 IgG 2gM Rapid Test Extemal Control Kit
C0180 each
EUR 520

Human COVID-19 Spike Protein IgG ELISA Test Kit
MBS1563048-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike Protein IgM ELISA Test Kit
MBS1563049-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike Protein IgA ELISA Test Kit
MBS1563050-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike Protein1 IgG ELISA Test Kit
MBS1563051-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike Protein1 IgG ELISA Test Kit
MBS1563052-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike Protein1 IgA ELISA Test Kit
MBS1563053-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike Protein2 IgG ELISA Test Kit
MBS1563054-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike Protein2 IgM ELISA Test Kit
MBS1563055-INQUIRE INQUIRE Ask for price

Human COVID-19 Spike Protein2 IgA ELISA Test Kit
MBS1563056-INQUIRE INQUIRE Ask for price

Human COVID-19 Nucleocapsid (NP) IgM ELISA Test Kit
MBS1563043-96Tests 96Tests
EUR 625

Human COVID-19 Nucleocapsid (NP) IgA ELISA Test Kit
MBS1563044-5x96Tests 5x96Tests
EUR 2805

Human COVID-19 Nucleocapsid (NP) IgA ELISA Test Kit
MBS1563044-96Tests 96Tests
EUR 630

COVID-19 (2019-nCoV) Coronavirus IgG/IgM Rapid Test Kit
GF101A1 25 Test/kit Ask for price

Diagnostic Sensitivity Test Agar
M502-100G 1 unit
EUR 17.21
Description: Diagnostic Sensitivity Test Agar

Diagnostic Sensitivity Test Agar
M502-500G 1 unit
EUR 48.4
Description: Diagnostic Sensitivity Test Agar

Truenat™ Chip-based Real Time PCR Test COVID-19
COVID-19 each
EUR 16

COVID-19 Ag Self-Test. Cs
R0182CST 1,2,5
EUR 1.65
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